The hypothalamus-pituitary-adrenal (HPA) axis controls the adrenal glands. There is an existing negative feedback loop that governs the amount of adrenal hormones secreted under normal circumstances. For example, the HPA axis adjusts cortisol levels according to the body's need via a hormone called Adrenal Corticotropic Hormone (ACTH). Website : https://www.drlam.com/articles/adrenal_fatigue.asp
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