disulfide bridges secondary structure - The disulfide bond plays an important role in maintaining the spatial three-dimensional structure of peptides and proteins and the biological activity determined thereby, and is also related to the stability and renaturation of proteins. Analysis of disulfide bonds and free sulfhydryl groups on proteins helps to analyze the high-level structure of proteins to reveal the biological functions of proteins. Disulfide bond analysis can analyze the structural characteristics of protein to improve its degradation stability and prolong its efficacy. The analysis of disulfide bonds in proteins is an important biochemical technology for biotherapeutic drug development projects. Related technical methods can be used to determine the location and content of disulfide bonds of biopharmaceutical proteins or other biological agents, thereby determining the structure and relative molecular content of proteins, and also measuring free thiol groups.
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